Monthly Archives: July 2009

Varicella zoster prevention

Passive immunization In 1978, VZIG prepared from the plasma of normal volunteers identified by routine screening to contain high antibody titers to VZV became available. Administration of VZIG to exposed individuals may prevent or reduce the intensity of disease. A

Varicella treatment

Acute, uncomplicated varicella in the young child is managed best by topical antipruritics such as calamine lotion, application of cool compresses, or by oatmeal baths. Children’s fingernails should be kept trimmed. Oral diphenhydramine sometimes is administered to help combat the

Central nervous system complications

CENTRAL NERVOUS SYSTEM Central nervous system complications also are seen in varicella. Cerebellar ataxia is the most common, with an incidence of approximately 1 per 4,000 cases in children younger than 15 years of age. It has an excellent prognosis.

Immunocompromised hosts

Varicella in the immunocompromised host can be severe and life-threatening. Cell-mediated immunity appears to be the most important factor in the prognosis of primary varicella infection, as evidenced by the fact that patients who have pure humoral immune deficiency syndromes

Varicella. Clinical Manifestations

PRIMARY INFECTION Primary infection with VZV produces the well-known clinical syndrome of varicella or chickenpox. Low-grade fever may precede the development of the rash by 1 to 2 days. The characteristic rash involves lesions that appear in crops and proceed

Varicella zoster virus

Varicella zoster virus (VZV) causes varicella, the most common exanthematous disease of childhood. After the acute infection, VZV remains latent in the dorsal root ganglia; reactivation of the virus later in life causes zoster. VZV is ubiquitous, and humans are