Monthly Archives: November 2008

Our primary hypothesis

Our primary hypothesis was that FM patients would perform more like older adults than their age-matched controls on many cognitive tasks. And the reason we gave them three blocks of tasks is that patients frequently complain about fatigue and we

FM patients

The study I’m going to talk about today … I’m going to try to give you a quick overview of the research protocol, because I’d really like to focus on the data. We had 20 FM patients, and you need

Fibromyalgia

Fibromyalgia is a rheumatic disorder characterized by musculoskeletal pain and tender points. Patients report substantial fatigue. They may be depressed. Some of them have sleep disturbances and poor cognitive function. It’s differentiated from chronic fatigue syndrome in that these patients

Dermatologic lesions

Disorders information There are dermatologic lesions that assist in diagnosis for you clinically. A very prominent one is adenoma sebaceum, which are angiokeratomas. They can have hypopigmented macules, ash-leaf spots, shagreen patches. We saw this picture earlier, with the ash-leaf

Cranial synostosis

Cranial synostosis. So here we first want to show you what the major sutures are. As you can see, here is the metopic suture, there is the coronal one going across, sagittal and the lambdoid, and there’s the anterior fontanelle.

Microcephaly

Microcephaly can have a variety of etiologies, depending on when you discover it. What I mean by that is some people are born microcephalic because they may have a chromosomal syndrome, or Cornelia de Lange or fetal alcohol, or one

Rare types of porphyrias

Porphyrias information 5-Aminolevulinic acid (ALA) dehydratase defect porphyria is a very rare type of porphyria that is caused by severe deficiency of 5-aminolevulinic acid dehydratase, the second enzyme of the heme biosynthetic pathway. It is inherited in autosomal recessive fashion,

Erythropoietic protoporphyria

Erythropoietic protoporphyria is manifested as acute photoreactivity of the skin in childhood. Typical symptoms are stinging pain or itching with subsequent swelling and erythema of the exposed skin within minutes to hours after sun exposure. Hepatobiliary complications may be associated

Porphyria cutanea tarda

Porphyria cutanea porphyria is the most common type of porphyria in the United States and Europe. Onset is usually during the fourth or fifth decade of life, and the disorder is manifested mainly as cutaneous symptoms and hepatopathy. Characteristic skin

Symptomatic Therapy

Symptomatic Therapy Patients with acute attacks usually have symptoms that may necessitate medication or other therapies. Pain is typically severe, often requiring opiate analgesics for control; morphine, meperidine, or other opiates in normal doses may be used. For insomnia, chloral

Treatment of the Acute Attack

Treatment of the Acute Attack Treatment of acute porphyric attacks includes three different approaches: elimination of precipitating factors, specific therapy, and symptomatic treatment. Elimination of Precipitating Factors Acute porphyric attacks are often precipitated by factors such as certain drugs, excessive