Monthly Archives: November 2007

Myoclonus

Now, myoclonus. Two types of myoclonus. If I had my hands like this and I had a needle in the extensor compartment of the arm and I hold it like this so it must be firing, because I’m extending my

Isaacs’ syndrome. Sandifer’s syndrome

Isaacs’ syndrome – Isaac was a man, by the way, a real man – Isaacs’ is a variant of stiff-person syndrome. It’s not an axial disturbance, it’s an appendicular disturbance. Much more distal but it’s a variant on the theme

PSP 2

Neuroid-acanthocytosis. Autosomal recessive. I like this disorder because it embraces a lot of different things. It embraces a little bit of a picture. These are the things, the acanthocytes, on a saline preparation in the blood. Just a smear with

PSP

PSP, the major features of that disorder there. To organize your trivia, I just gave you that little vignette a little while ago. You know what I mean by supranuclear gaze palsy, you know that there is a difference in

Multiple system atrophy

I mentioned to you before. A constellation of three entities; Shy-Drager, which in the older nomenclature was going by the term idiopathic orthostatic hypertension, or pure anatomic failure. Olivopontocerebellar atrophy, or PCA, striatal nigral degeneration. The clinical picture of these

Hallervorden-Spatz disease

Now why you should be inclined, if you are not a movement disorders person, ever to worry yourselves about Hallervorden-Spatz disease I’ll never know. But it is associated with a very characteristic MR. It literally looks like there are tiger’s

Cortical basal ganglionic degeneration

Cortical basal ganglionic degeneration is a very weird disorder, very weird disorder. It is the only movement disorder in which it behooves you to do a sensory examination and a cortical sensory examination. It has been associated with these weird,

Wilson’s disease

Wilson’s disease is in the differential diagnosis of parkinsonism that presents early. It has certain characteristic features, including this really weird wind- beating tremor, this odd sort of spastic gait. It has a mix of parkinsonian and long-tract spastic signs.

New Treatments for Movement Disorders. Part 8

Supranuclear gaze palsy. We are talking about PSP. Supranuclear gaze palsy. Some associations. If the supranuclear gaze palsy happens, what is a supranuclear gaze palsy? Look at my hand, follow my hand down. Follow my hand up. So it is

New Treatments for Movement Disorders. Part 7

Just a couple of very fatuous concluding observations. There are a number of therapeutic options in Parkinson’s disease and the fact that there are so many of them that we are talking about means that we haven’t found a cure.

New Treatments for Movement Disorders. Part 6

Now as a result of this diagram, now you can become quite confused because in the direct system you have two inhibitions back-to-back. Two negatives, as it were, equaling a positive. Oh, how complicated. Let me try to make it

New Treatments for Movement Disorders. Part 5

So how do we understand these phenomena that we see? Now we can go to a review of the pathways. I actually like to draw it out, so I’m going to go to the overhead momentarily. But it begins with